Assuming you are using WIN2000 which is listed in your profile
Sometimes the Local Security Policy database cannot locate files that are hard-coded to show the path, such as C:\winnt\Security. Therefore, these files must be deleted. They are in the C:\winnt\Security directory and appear as edb.log, edb00008.log, res1.log, and res2.log.
After you delete the files, restart the system.
Access the Local Security Policy and the files are regenerated with the correctly coded path of “YourRemappedDriveLetter”:\winnt\security.
http://support.citrix.com/article/CTX101930
If that does not apply look over this article
http://support.microsoft.com/default.aspx?scid=kb;en-us;278316
Is the file system FAT32 or NTFS
Sometimes the Local Security Policy database cannot locate files that are hard-coded to show the path, such as C:\winnt\Security. Therefore, these files must be deleted. They are in the C:\winnt\Security directory and appear as edb.log, edb00008.log, res1.log, and res2.log.
After you delete the files, restart the system.
Access the Local Security Policy and the files are regenerated with the correctly coded path of “YourRemappedDriveLetter”:\winnt\security.
http://support.citrix.com/article/CTX101930
If that does not apply look over this article
http://support.microsoft.com/default.aspx?scid=kb;en-us;278316
Is the file system FAT32 or NTFS