well, Im assuming this is email that you have trough your ISP so you can set outlook to check your mail every so often. You should also be able to use autorespond feature. Im not sure which version you have but you should have something like out of office assistant. When you start it up, you can setup what kind of email would you like to autorespond to and similar.....or, you can use IE and go to your ISP's website, log into your email and configure your mailbox there to autorespond with a vacation message.