Couple of things to check out,,,,,,,
Your temps, make sure they are acceptable and please post them here for us to review.
Check the case fans too by disconnecting them one at a time.
Note: Do not disconnect the cpu fan to check
Your temps, make sure they are acceptable and please post them here for us to review.
This makes me think it is the cpu fan that is bad and causing the noise because as you increase cpu usage the fan could speed up and the noise would also if you are Amd's cooln quiet
Check the case fans too by disconnecting them one at a time.
Note: Do not disconnect the cpu fan to check