Setup the large hard disk to "sleep" after 5 or 10 minutes of not being used. You will get no "wear" on the hard disk while it is sleeping--you will have to wait 7 -9 seconds for the hard disk to "wake up" after being asleep, but compared to the hours or days it was in sleep mode before you needed it, that short wait to access the hard disk is not much of a problem unless you need something every 15 minutes or something. Some newer devices need exFAT for compatibility, particularly on removable media (USB memory devices for example). If the data on the hard disk is important, consider a RAID hard disk enclosure. Just add a second hard disk and the RAID operation will automatically replicate everything on the second hard disk and maintain the same data on both hard disks as you use the system. If one hard disk fails, you just insert a new hard disk, setup the format, and RAID will re-establish a copy of all the data on the new hard disk. Also note that different external hard disk enclosures offer different levels of performance. For example, a Western Digital MyCloud setup as a RAID device is not fast enough to stream video files created from UHD/4K sources on discs. A 2 hour movie can have as much as 50-85 GB of video and audio data and while the WD MyCloud device is reliable and suitable for documents and photos where peak speeds aren't as much of a concern, they just don't move enough data by Ethernet connections for the highest-res video and audio. I had to change to Netgear ReadyNAS 4-series drive enclosures in order to stream UHD/4K video reliably with up to 13 channels of sound in TruHD/Atmos, DTS:X/HD-MA, or Auro-3D/Auromatic.