Try running it using 95/98 compatiblity mode. If it needs a patch, go to the official Lego download site.Windows XP/Vista compatibility
Older versions of Lego Creator CDs do not work in Windows XP unmodified. When installed from an original game disc, overwritten with a third party patch and run in Windows 98/Me compatibility mode, the game will play on some Windows XP computers. Lego has released a newer edition which is XP compatible and has also released a patch to allow it to run on Windows-NT based operating systems, such as Windows 2000, XP or Vista. Lego creator is compatible with Windows Vista Home Basic and Windows Vista Business.