In what sense ?
My guess is as long as it has proper ventilation, as it should anyway, the only thing will be the battery running down, obviously you can use the hibernate etc to minimise any drain on the battery, but if your running it from the mains I have a recollection of something about it's best not to use the battery (unplug it from the laptop) at the same time, now some laptops mains are tied to the battery where you have no option, I can't recall the reason but I remember seeing it a while back, it will probably be wise to close the screen down as well so it isn't active, like you would turn off a monitor, because if no ones there it's pointless not to mention it will prolong it's life that way (not that you may notice), hope this helps a bit anyway.
My guess is as long as it has proper ventilation, as it should anyway, the only thing will be the battery running down, obviously you can use the hibernate etc to minimise any drain on the battery, but if your running it from the mains I have a recollection of something about it's best not to use the battery (unplug it from the laptop) at the same time, now some laptops mains are tied to the battery where you have no option, I can't recall the reason but I remember seeing it a while back, it will probably be wise to close the screen down as well so it isn't active, like you would turn off a monitor, because if no ones there it's pointless not to mention it will prolong it's life that way (not that you may notice), hope this helps a bit anyway.