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Since you don't have specifics listed with regard to what you're powering, I'll stick with general notes as well.
If you're running dual processors you'll want to ensure that you have the appropriate auxiliary power connectors available (usually an 8-pin EPS connector in addition to the standard 4-pin 12V CPU connector). Another issue to be aware of is balancing the load on the 12V rail(s). A PSU with multiple rails can present a problem to high-draw dual processor boards which also utilize GPUs requiring auxiliary power connectors. Fewer rails typically make it easier to balance the load on the supply.
If you're running dual processors you'll want to ensure that you have the appropriate auxiliary power connectors available (usually an 8-pin EPS connector in addition to the standard 4-pin 12V CPU connector). Another issue to be aware of is balancing the load on the 12V rail(s). A PSU with multiple rails can present a problem to high-draw dual processor boards which also utilize GPUs requiring auxiliary power connectors. Fewer rails typically make it easier to balance the load on the supply.