Im assuming you want the touchpad to be disabled and you would like to use a mouse. You could try going into your BIOS and see if there is a setting that will not allow it to use both at the same time and disable the touchpad when a mouse is plugged in.
I was trying to do this to mine a couple of months ago and after a lot of research I discovered the only way was to physically unplug it by dismantling the computer. With some computers it is probably possible as the previous replies say.
I wonder if there is any program out there that could disable it. If you cant find anything to disable it i suppose you could cover it with something, but that could get annoying. Yeah with my HP theres just a button right above the touchpad and i just have to push that to disable it.
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