Without know the error its kinda hard, but here are some stuff I got from http://techsupport.vuinteractive.com/techsupport/sierra/support.asp
"engine start mfc app has encountered a problem and will now close"
If you encounter this error, download the update available at:
System Running Too Fast For The Game.
This is caused by your system running too fast for the game. The older games were written before today's faster computers existed. They were programmed on slower systems, so the areas that have timers in the programming or require scripts to be played out at a certain speed may have trouble with very fast systems.
For this reason, we have placed some saved games for Space Quest 1(VGA) on the site listed below. All you need to do is save the file to your hard drive. Once the file is downloaded, double click the icon for the downloaded file and it will begin the extraction process. If a default install of the game was done (i.e. no changes were made during the install) it will be this path:
If the game is installed to another drive or directory, please modify the extraction location as necessary. Once extracted into the directory, the save games will be accessible through the 'Restore' screen of the game. The saved games included are listed below for your convenience. Please refer to the readme file for additional information.
Save 1 - After Roger has reached the caverns on Kerona for the first time.
Save 2 - After Roger has passed the acid drips for the first time.
Save 3 - After Roger arrives back in the caverns for the second time.
Save 4 - After Roger passes the drips for the second time.
Save 5 - After the skimmer sequence.