no devices (in device manager)are not loading.
Are you talking about the Device Manager, or the Task Manager?
Try running chkdsk /r.
See if the system restore is enabled and that you have sufficient harddives space alloted for it to have restore points. If it looks OK, then run your antimalware software.
Malware will often disable the system restore function. Run more than one malware programs. I use SuperAntiSpyware and SpyBotS&D. Others are good also.
Look in the event viewer and see if there are any relevant errors listed under either sytem or applications. Double click on the errors to get more details.
Keep us posted on the results.