Disable hibernation in control panel>power options
Set virtual memory initial size to 0, set maximum size to 0- (click the set button)
Start>right click My Computer>properties>advanced tab>in the performance box>settings>advanced tab>virtual memory box
Turn off system restore
Defrag drive- if your internet is cable or dsl-disconnect modem, disable antivirus software first (should already be disabled if you are in safe mode)
Re-enable all of the above- set virtual memory initial and maximum size to 1.5 or 2 times physical memory
That's about as thorough a defrag environment as you can get. The only other caveat is that the defragger moves and organizes data fragments so that all parts of fragments of files are contigous with all other fragments as opposed to just moving the fragmanets of files so that the data area is contigous
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