If you're using two GPU's,remove one and see how it goes.
PC Specs?
Pre-Built Brand & Model Number
Custom Built-Brand & Model of Mobo-CPU-RAM-Graphics-PSU.
I assume the 6GB of RAM is sX2? If so, try removing one of the sticks. Your Mobo is Dual Channel and 4GB is more than enough for any game.
If you have a 2 and 4GB stick try removing the 4GB stick.
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