I have a Dell Latitude E6430 laptop where only really one the USB ports works reliably in normal mode, the one on the right side on the right https://www.dell.com/support/article...-guide?lang=en
Either my USB mouse or my USB flash drive will work in it, almost immediately, without any issues, the other two have problems. But, the USB drive and the mouse will work in ALL 3 ports with no problems at all in safe mode, just not in normal mode for Windows 7 Professional 64-bit (working on upgrading to 10, just have to do some things first)
Sofar, what I've tried is uninstalling the USB host controllers and the root hubs in device manager and turning them back on. That didn't work so well, a few times I got BSOD's when I plugged in a device in the USB ports, one time I got one when NOTHING was plugged in, another time when the mouse was plugged in. Isn't there a tool that tracks them? Maybe I can give you information about them.
Just wondering why only one of the ports work reliably, also why do I have duplicate entries in the USB controller screenshot I've attached?
Maybe this could be helpful, just not sure what steps to do, if some of them are working in safe mode.