I had a perfectly ok working Vista 64 Home Premium (SP1) with an Optiarc DVD-RW. This recently stopped working properly and the only thing I remember doing at the time was trying to install VMWare Server (and then un-installing when I discovered that the drivers weren't signed). This install did ask about removing Autoplay, another reason for it being a suspect.
The symptoms are that when a DVD-ROM, CD-ROM or Music CD is inserted it recognises that there is something in the drive as can be seen in Explorer by noting a '0 bytes free of ...' message below the device name. If you double click, it treats it like a writeable disk and asks for a title. If you try to access the disk by typing the path into the address bar, it is able to do this without an issue. Game disks are not recognised by an icon change, but will still run from installed icons (so it can verify the disk is in the drive).
I have checked the Autoplay options in the control panel (I can't find any directly associated with the drive) and all settings are default.
I did find and try:
and it appeared to work for whatever disk was inserted on boot, but no other (though I didn't do extensive testing).