Hi Starhunny, and welcome to TSF!
Could you please post your system specs [use the link in my signature], and include sound cards etc.
While you're at it, try this....
Right click on 'My Computer' on the desktop > Properties > Hardware > Device Manager > View > show hidden devices, and have a look and see if there are any Yellow ! marks or Red X's next to anything in the list; particularly in 'sound, video and game controllers'.
Double check that you didn't accidently knock the soundcard when you installed the second HDD. [It's very easy to do..I've done it many a time
Please post back with the results.