It should be safe to do so, yes - but further details are needed to find out exactly what software they belong to. Also, uninstalling the software is better than removing parts of it; re-run Malwarebytes again after the uninstall and a reboot to ensure all parts are removed.
If you've removed exactly the same in the past, do they belong to a software you intentionally downloaded/used? If not, I would advise a full Malware checkup: NEW INSTRUCTIONS - Read This Before Posting For Malware Removal Help - Tech Support Forum
Looking at the 'Software.Updater' part of the descriptor, I can only think of 2, maybe 3 software updaters that I would class as reasonably safe and effective (I use Secunia PSI: Free Computer Security - Personal Software Inspector (PSI) - Secunia
); there are probably others that are 'copycat' of those or are less-well written/designed and/or come with 'piggyback' software or are from a disreputable company.