There are application that you can run to tell you what program is using each one of those connections.
Fport should help identify what programs are using all those connections.
http://www.foundstone.com/knowledge/proddesc/fport.html
Active Ports can do the same thing.
http://www.protect-me.com/freeware.html
TCPview from Sysinternals will help as well.
http://www.sysinternals.com/Utilities/TcpView.html