Raylo

That's not a bad thought, Bud. My 1994 S-10 4.3 P/U had a similar wire problem. The auto trans shift linkage impinged on the big wiring harness coming through the firewall in the engine compartment and wore a hole through the outer bundle insulation and the insulation on one wire. In my case I didn't get a no-run, I got a blown fuse every time I shifted from D to OD (when the linkage hit the bare wire and grounded) and a tranny that didn't shift to OD and some other gears. Basically it killed the electronic contol of the tranny and it just operated in some sort of limp mode purely on hydraulics. It's very tight back there but I was able to loop a piece of wire around the bundle and pull it away from the linkage and tie it off, then tape over the bare wire.

It wouldn't hurt all 4.3 owners from that era to have a look at this and/or include as part of basic troubleshooting, especially if you are getting any mystery blown fuses, since it could cause any number of issues. Bottom line is they installed the harness improperly and depending on what wire you bare and ground out pretty much anything can happen.

BTW, my truck was assembled in the Louisiana plant so perhaps it is more likely to affect 4.3 S-10 vehicles with that pedigree.