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RUNNER ERROR
Could not load the target dll ("C:\Program Files\Desktop Messenger\8876480\6.1.0.155-887640L\Program\backWeb.dll", error code 126)
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Have Hijackthis fix this entry. It will stop those errors.
O4 - Global Startup: Logitech Desktop Messenger.lnk = C:\Program Files\Desktop Messenger\8876480\Program\LDMConf.exe
Logitech's Desktop Messenger is not something that you need nor want to start automatically with Windows.
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running incredibly slowly and shutting down randomly with the blue screen o' death.
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Those issues should have stopped after ComboFix's first run. Rootkits like runtime.sys will create symptoms like that.
Are you still getting bluescreens?
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